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KMID : 0043319990220040428
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Archives of Pharmacal Research
1999 Volume.22 No. 4 p.428 ~ p.431
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Anticomplement Activities of Oleanolic Acid Monodesmosides and Bisdesmosides Isolated from Tiarella polyphylla
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Park Si-Hyung
Oh Sei-Ryang
Jung Keun-Young
Lee Im-Seon
Ahn Kyung-Seop
Kim Jae-Gil
Lee Jung-Joon
Lee Hyeong-Kyu
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Abstract
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Seven known oleanolic acid glycosides (1-7) were isolated form the MeOH extract of Tiarella polyphylla. The structures were identified to be 3-O-(-glucopyranosyl) oleanolic acid (1), 3-O-[-D-glucopyranosyl-(1 3)--D-glucopyranosyl] oleanolic acid (2), 3-O-D-[-D-glucopyranosyl-(1 2)--D-glycopyranosyl] oleanolic acid (3), 3-O-[-D-glucopyranosyl-(1 3)--D-glucopyranosyl] oleanolic acid 28-O-D-glucopyranosyl ester (4), 3-O-[-D-glucopyranosyl-(1 2)--D-glucopyranosyl] oleanolic acid 28-O--D-glucopyranosyl ester (5), 3-O-[a-L-rahmnopyranosyl-(1 3)--D-glucururonopyranosyl] oleanolic acid (6), and 3-O-[-L-rhamnopyranosyl-(1 3)--D-glucuronopyranosyl] oleanolic acid 28-O--D-glucopyranosyl ester (7) on the basis of physicochemical and spectral data. These triterpene glycosides were tested for the anti-complement activity and hemolytic activity. Bisdesmosidic saponins, 4, 5, and 7, showed anti-complement activity; in contrast, monodesmosidic saponins, 1-3, and 6, showed direct hemolytic activity. Methyl esterified monodesmosidic saponins showed anti-complement activity at a low concentration and hemolytic activity at a high concentration.
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KEYWORD
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Tiarella polyphylla, Saxifragaceae, Saponins Anti-complement activity
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